(this page
is still being developed) (this page
is still being developed)
Multiple pregnancy rate is one of the most important problems in present assisted reproduction. It is well known that increasing the number of transferred embryos increases both pregnancy rate (PR) and multiple pregnancy rate (MPR). However, until now, the increase in MPR associated with the increase in PR linked with the transfer of more embryos as not been quantified. On the other hand there is a great variability in both PR and MPR among the different IVF groups. In a recent work ("Mathematical prediction of pregnancy and multiple pregnancy in IVF, based on the implantation rate and the number of transferred embryos" to be published in xxxx. A MS Word copy of the article can be found here.) we have found that embryos help each other during implantation and we have developed a mathematical model that accurately predicted PR and MPR.Introduction:
Mathematical model:
The mathematical model is intended to predict the pregnancy rate as well as the different multiple pregnancy rates ( twins, triplets, quadruplets,..) expected when a specific number of embryos are transferred, taking into account the specific implantation rate (IR) obtained in the same clinical setting (when the same specific number of embryos are transferred)Since this model cannot be expressed with a simple formula, this page provides different Excel spreadsheets, one for each of the models discussed in the text. These spreadsheets can be freely downloaded. Following the instruction in the sheets, the parameter or parameters of the model can be varied obtaining the probabilities as a function of the transferred and implanted embryos.
We cannot currently provide the full program to get the best parameters that fit your data. You must by hand vary them and compare prediction and observation.
Alternatively you can e-mail us your data including your name, hospital and any information regarding the procedure that might be interesting. We will answer back the results (we guarantee not making them public without your permission).If you use any of these files for any public result, please do not forget to refer to our publication. Feed-back and suggestions are welcome.
Click on the model below, to obtain an excel spreadsheet, that provides the different probabilities as a function of the parameters. (see the full article for explanation of each model):
Binomial Ground Collaborative
This page and their contents is created and maintained by Roberto and Francisco Matorras at the "Instituto de Fisica de Cantabria" server.